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TAK-243 preferentially certain to UBA1 more than the linked E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lowered amounts of ubiquitylated proteins, enhanced markers of proteotoxic strain and DNA harm anxiety. In vivo, TAK-243 reduced leukemic stress and specific leukemic stem cells devoid https://rnaiii-inhibiting-peptide44321.thelateblog.com/29452936/what-does-isorhamnetin-3-o-glucoside-mean

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